Main content
Pertussis vaccine
Want to join the conversation?
- In the last video, why would you get percussis if you had the vacine? wouldn't you not get it?(3 votes)
- “We’ve had over 90% baby vaccination rates for whooping cough vaccines for over 11 years…since 2000, AND they’ve included even more shots since then for the adolescents at the time… and yet more, after 2000… AND here we are with whooping cough in EVEN higher numbers than it was before 1960? Don’t you think that’s absolutely astonishing? …Australia, which has had over a 95% whooping cough vaccination rate since 2000, is having the largest outbreak in their history since pertussis vaccination started. The same is happening in USA, and their rate of vaccination is even higher than Australia. So what do you think is happening there?” – Hilary Butler(0 votes)
- Change in vaccine and increasing numbers of ignorant people who choose not to vaccinate, decreasing herd immunity. Vitamin C is more useful in treating scurvy and not for bacteria infections(5 votes)
Video transcript
- [Voiceover] Lets start with summarizing what we discussed up
until now about Pertussis. Pertussis is caused by
a microscopic bacteria having a rod-like shape
like I'm drawing here. It's a highly contagious upper respiratory tract infection transmitted
through aerosols or by touching the eyes,
nose, or mouth with an infection source like this man's hands. And bacteria damages
airways and allows mucus to build up in the airways
until it's forcefully removed by violent coughing
fits followed immediately by a whooping noise when
the air is finally able to come back into the lungs after a fit. We also discussed that
the clinical symptoms of Pertussis infection can
last around twelve weeks and these weeks are broken
down into three stages depending on the clinical
symptoms present. But we also talked about
a few modifying factors. A modifying factor can be anything that makes these three stages difficult to tell apart because
the symptoms are milder and the transmission rate is lower. So, one of these factors was previous infection with a disease. So, let's say that the
dad of the family here was infected with
Pertussis a few years ago, and his body, like yours
or mine, would mount an immune response by making
antibodies against Pertussis. These antibodies are like specialized tags that attach specifically
onto the Pertussis bacteria and proteins produces and
flags them for destruction. Once that clears the infection,
he's left with a level of Pertussis antibodies in his
body for a long time after. So, let's give him an antibody badge here to remember that he has
immunity against Pertussis. This means that if he's
reinfected with Pertussis his immune system is ready
or primed for the infection and can fight it more quickly so he becomes less contagious because he kills the disease faster, and the classically clinical symptoms of the disease become milder
or may not occur at all. Now is a good time to bring in the rest of the family to discuss another modifying factor which is vaccine history. Vaccines are like training
with practice runs so that you'll be able
to handle the marathon meaning let's say that grandpa had a Pertussis vaccine recently. The vaccine causes his
body to produce antibodies against the bacteria and proteins a lot like a true infection would but this way if he's ever exposed to a natural Pertussis infection or in the analogy, a marathon, his body's primed to
fight just like dad's. So, he has an antibody badge too. But there are a few
Pertussis vaccines out there and they vary in their components
that make up the vaccine even though they have all the same goal of generating antibodies
against Pertussis. So starting with the whole
cell Pertussis vaccine. Sometimes this is abbreviated
WP for whole cell Pertussis. It contains the entire
dead Pertussis bacteria with the majority of its proteins. Then it's given in a
series of four vaccines between two months and fifteen years old. And while this series if about
seventy and ninety percent effective in preventing a
serious Pertussis infection it also had a high
incident rate of discomfort at the injection site and mild Pertussis-like symptoms
following the vaccine. Seeing that it's (mumbling)
it's been phased out and it's been replaced by
acellular Pertussis vaccine or abbreviated A for acellular Pertussis. These vaccines contain just
pieces of Pertussis bacteria and some of the proteins
and protein-based toxins made by the bacteria that
we discussed previously. Which proteins and toxins
are in a particular vaccine depend on the manufacturer. And there are two vaccines that fall under this acellular category. They're both given with diphtheria tetanus which is why they have a D and
a T appearing in their names. They're DTaP and Tdap, and there are a few differences
between the two vaccines. To start with, this capital P
instead of a lowercase p here represents a higher dose of
Pertussis in the DTaP vaccine. This higher dose is given in a series of five vaccines at two,
four, and six months, and some are between
fifteen and eighteen months, and then again between
four and six years old. This series is eighty to
eighty five percent effective in preventing a serious
Pertussis infection but it has less side effects than the whole cell Pertussis vaccine. It's important to know that
neither natural exposure nor any vaccine will give a person a hundred percent immunity to Pertussis. This is because over time antibody levels in the body drop to a point where they're, they aren't as protective. So, to avoid this from
happening there's the Tdap. Tdap is a booster that should be received every five to ten years and the last infection or vaccination. I like to think of the boosters as, like, our refresher course. You take a refresher course when you've already studied
some material on point but you need to see it
again to jog your memory. Booster does the same thing. Grandpa may have had a Pertussis infection when he was younger but
the booster's needed to refresh his body's
memory against Pertussis and bump up his antibody levels which tend to fall throughout the years. Everyone should take care
to get a booster on time but there are some groups
who should be extra careful. Those who have underlying
respiratory disease, those who are amino-compromised, or let's say grandma
is a healthcare worker and since immunizing can
help prevent the spread of Pertussis from one person to another, she should take care to be vaccinated. And really anyone in this
family should be vaccinated 'cause they're gonna be around an infant that they don't want to infect. Lastly, expecting moms at twenty seven to thirty six weeks at
each of their pregnancy you should get the Dtap
because the antibodies that mom produces in response can be passed along to the baby. Then when the baby is born the baby will have some protective passive immunity to Pertussis until he or she can receive the first Pertussis vaccine at two months. Outbreaks for Pertussis are on the rise and though there is a school of thought that Pertussis bacteria is mutated making the available vaccines less efficient it's largely due to children
not getting vaccinated and adults not receiving their boosters. So, this makes transmission
of the infection high and symptoms and complications
from infections more severe.